Web24 May 2024 · The transporter SPNS2 is required to supply S1P to lymph, but is dispensable for the bulk of blood S1P (ref. 5).In Spns2-deficient mice, circulating T cells exit the spleen … Web21 Apr 2024 · SPNS2 in βENaC mice was sharply reduced (38%, p < 0.05) and lost apical localization at sites of mucus obstruction. A significant (34%; p < 0.01) decrease in epithelial SPHK2 was also noted at mucus obstruction sites. Conclusion These results support that mucus obstruction may enhance NLRP3 inflammasome activation and dysregulated S1P …
Mouse SPNS2 Functions as a Sphingosine-1-Phosphate …
Web29 May 2024 · We conclude that a protein complex of Mfsd2a and Spns2 can improve the efficiency of S1P transport in brain ECs. Efficient transport by Spns2 and Mfsd2a … Web16 Feb 2024 · SPNS2 is a cell surface protein that transports intracellular S1P to blood and lymph, where S1P acts as a bioactive lipid mediator that binds to its G-protein-coupled … mohawk college calendar 2022
SPNS2 - Wikipedia
WebDuring an inflammatory response, lymphocyte recruitment into tissue must be tightly controlled because dysregulated trafficking contributes to the pathogenesis of chronic disease. Here we show that during inflammation and in response to adiponectin, Web12 Mar 2012 · Spns2 regulates egress of immature B cells from the bone marrow into the blood. In the late stage of B cell development in the bone marrow, newly generated immature B cells are exported into the peripheral blood in an S1P/S1P1 signal–dependent manner ( … WebRGD ID: Symbol: Name: Description: Chr: Start: Stop: Species: Annotations: Match: Type: 628882: Elac2: elaC ribonuclease Z 2: 10: 49632308: 49655614: Rat: n/a: Region ... mohawk college bus pass