Webb11 apr. 2024 · The process of converting LC3 I to LC3-II, which requires the addition of phosphatidylethanolamine, ... SuiX Z. RSL3 drives ferroptosis through GPX4 inactivation and ROS production in ... JS, Galicia-Velasco M, Aguilar-Cazares D. The double-edge sword of autophagy in cancer: from tumor suppression to pro-tumor activity. Front ... WebbIntroduction. Ferroptosis is an iron-dependent and non-apoptotic form of cell death defined in 2012. It is characterized by excessive accumulation of lipid peroxides and reactive oxygen species (ROS). 1 Ferroptosis differs from apoptosis, necrosis, and other types of cell death in terms of morphology, genetics, metabolism and molecular biology. 2 …
Polyunsaturated fatty acid biosynthesis pathway determines …
WebbThe disease databases, including GeneCards, 40 OMIM, 41 TTD, 42 CTD 43 and FerrDb, 44 were used to screen the depression and ferroptosis-related targets. Then, each target of active ingredients, depression and ferroptosis were searched in the UniProt database 45 to get the UniProt gene ID. Here, 12,608 depression-related targets and 260 ferroptosis … Webb16 apr. 2024 · Ferroptosis is one of these programs triggered by dyshomeostasis of three metabolic pillars: iron, thiols, and polyunsaturated phospholipids. This review focuses on: (1) lipid peroxidation (LPO) as the major instrument of cell demise, (2) iron as its catalytic mechanism, and (3) thiols as regulators of pro-ferroptotic signals, hydroperoxy lipids. patch anti inflammatoire talon
Full article: Ferroptosis: machinery and regulation - Taylor & Francis
Webb24 nov. 2024 · Aguilera et al. show that ferroptosis, ... The 50°C-HS induced the accumulation of oxidized species of phosphatidylethanolamine (PE; 36:4-OO and 36:5-OO) and phosphatidylglycerol (PG; 34:2-O, 34:2-OO, ... Lipidomic studies have identified oxidized arachidonic/adrenic PEs as pro-ferrototic signals in human cells (Kagan et al., ... WebbThis review is focused on iron metabolism in the retina and in the lens and its relation to their respective age-related pathologies, macular degeneration (AMD) and cataract (ARC). Several aspects of iron homeostasis are considered first in the retina and second in the lens, paying particular attention to the transport of iron through the blood-retinal barrier … Webb1 okt. 2024 · Ferroptosis is a type of nonapoptotic and iron-dependent regulated cell death that can propagate between cells, thereby affecting entire cell populations [1]. … patch antenna equivalent to simple monopole