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WebPanIN 1A and 1B are common incidental findings May be found in up to 40% of noncancerous pancreata; Natural history of PanIN 2 and 3 is not known; PanIN 3, at least, may be a precursor to invasive ductal carcinoma Rare in noncancerous pancreata; Present in 30-50% of pancreata with invasive carcinomas WebMay 13, 2024 · To dissect the mechanisms whereby Arid1a knockout drives PanIN progression, we applied the single-cell RNA-seq method to profile the transcriptome of individual early-stage PanIN lesions from Arid1a knockout and wildtype mice. Our results showed that Arid1a knockout could effectively reduce KRAS-induced senescence in … synchrony bank login retailer

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