Gsea myc

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August undefined, 2024

WebHuman Gene Set: BILD_MYC_ONCOGENIC_SIGNATURE. Standard name. BILD_MYC_ONCOGENIC_SIGNATURE. Systematic name. M2069. Brief description. Genes selected in supervised analyses to discriminate cells expressing c-Myc [GeneID=4609] from control cells expressing GFP. Full description or abstract. WebThe MYC transcription factor regulates a vast number of genes and is implicated in many human malignancies. In some hematological malignancies, MYC is frequently subject to missense mutations that enhance its transformation activity. Here, we use a novel murine cell system to (i) characterize the transcriptional effects of progressively increasing MYC …

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WebJun 15, 2024 · Six Hallmark cell proliferation-related gene sets (G2M Checkpoint, E2F Targets, MYC Targets V1 and V2, Mitotic Spindle, p53 pathway) defined by MSigDB in … WebStandard name. KIM_MYC_AMPLIFICATION_TARGETS_UP. Systematic name. M8445. Brief description. Genes positively correlated with amplifications of MYC [GeneID=4609] in SCLC (small cell lung cancer) cell lines. Full description or abstract. DNA amplifications and deletions frequently contribute to the development and progression of lung cancer. To ... arasinakere

Androgen receptor and MYC equilibration centralizes on ... - Nature

Web2.2.3.1. About Background genes¶. By default, all genes in the gene_sets input will be used as background.. However, a better background genes would be the following: (Recommended) Input a list of background genes: [‘gene1’, ‘gene2’,…] WebCluster 7: genes up-regulated in B493-6 cells (B lymphocytes) by MYC [GeneID=4609] and down-regulated by the combination of MYC and serum. Full description or abstract Proliferation of higher eukaryotic cells is triggered by the proto-oncogene c-myc (myc), which is induced downstream of a large number of growth factor receptors. WebThe c-Myc oncogenic transcription factor stimulates proliferation and growth by activating thousands of target genes. Here we demonstrate that TFRC1 is a critical downstream target of c-Myc. Using in vitro and in vivo models of B-cell lymphoma, we show that TFRC1 expression is activated by c-Myc. Chromatin immunoprecipitation experiments reveal ... arasi maran

Mannose metabolism inhibition sensitizes acute myeloid …

2. GSEAPY Example — GSEApy 1.0.0 documentation - Read the …

WebApr 29, 2024 · RNA-sequencing (RNA-seq) and Gene Set Enrichment Analysis (GSEA) analyses indicated that BCAT1 overexpression activated Wnt/Myc signaling. Western blot revealed that BCAT1 increased protein expression of MMP7, cyclin D1, c-Myc, and decreased E-cadherin and p27 in the BEAS-2B and H1299 cell lines. Further … WebGSEA Desktop Tutorial. We are in the process of rewriting this tutorial. In the meanwhile, please refer to our User Guide for information on how to use the GSEA Desktop. arasi lodge karurWeb15 hours ago · a GSEA showed the activities of the CORE, MYC, and PAF modules (upper) and the PRC, TBX, and PCGF modules (lower) in mESCs relative to 12-day EBs. arasinakunte pincode

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Gsea myc

SCHLOSSER_MYC_TARGETS_AND_SERUM_RESPONSE_DN - gsea …

WebStandard name. PID_MYC_REPRESS_PATHWAY. Systematic name. M254. Brief description. Validated targets of C-MYC transcriptional repression. Full description or abstract. Collection. C2: Curated. Web2 days ago · GSEA analysis confirmed that MYC signaling pathway was one of the enriched gene signatures in HIF1A-As2 KD gene sets (Supplementary Fig. ...

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WebMember Login. Please enter your email to login or create an account. Email Address. continue. Are you a CSEA employee? Login here. WebSMYD2 knockdown cells were established to identify the effects of SMYD2 on cell growth in vitro and in vivo. GSEA and RNA sequencing were adopted to reconnoiter the signaling regulated by SMYD2 in PCa. The relationship between SMYD2 and c-Myc was examined by western blot analysis, qPCR, and immunohistochemistry.

Web201 rows · Human Gene Set: HALLMARK_MYC_TARGETS_V1. For the Mouse gene set with the same name, see HALLMARK_MYC_TARGETS_V1. Standard name. … WebApr 12, 2024 · The Myc-TAZ and TAZ deletion constructs and TEAD reporter plasmids were generated in our previous study . ... For gene set enrichment analysis (GSEA), the GOBP_HIPPO_SIGNALING gene set was applied ...

WebGene Set Enrichment Analysis (GSEA) is a computational method that determines whether an a priori defined set of genes shows statistically. significant, concordant differences …

WebThe importance of Myc in growth control is well established. However, the number of growth control genes requiring Myc as an essential factor for regulation after mitogenic stimulation of cells is not yet clear. Here, we have studied the transcriptional programme of a human B-cell line, P493-6, in response to Myc and serum.

WebSep 21, 2024 · GSEA requires as input an expression dataset, which contains expression profiles for multiple samples. While the software supports multiple input file formats for these datasets, the tab-delimited GCT format is the most common. ar asinWebStandard name: MYC_Q2: Systematic name: M17805: Brief description: Genes having at least one occurrence of the motif CACGTGS in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb]. arasimaennWebOct 7, 2024 · Gene ontology (GO) gene set enrichment analysis (GSEA) of genes, ranked by log 2 fold change, was performed for each of the five MYC-induced transgenic mouse tumor models. Heatmap shows the GSEA ... aras indonesiaWebStandard name. DANG_MYC_TARGETS_UP. Systematic name. M6506. Brief description. Genes up-regulated by MYC [GeneID=4609] and whose promoters are bound by MYC, according to MYC Target Gene Database. Full description or abstract. We report a database of genes responsive to the Myc oncogenic transcription factor. arasi malingaWebDec 15, 2024 · As expected, GSEA showed that the set of genes that were decreased after MYC depletion was enriched for DHT-repressed genes, consistent with MYC downregulation contributing to the DHT-repressed ... bakel huisartsWebHuman Gene Set: LEE_LIVER_CANCER_MYC_E2F1_DN. Genes down-regulated in hepatocellular carcinoma (HCC) from MYC and E2F1 [GeneID=4609;1869] double transgenic mice. Genetically modified mice have been extensively used for analyzing the molecular events that occur during tumor development. arasinWeb59 rows · Human Gene Set: HALLMARK_MYC_TARGETS_V2. For the Mouse gene set with the same name, see HALLMARK_MYC_TARGETS_V2. Standard name. … ara singer