WebNational Center for Biotechnology Information WebIn order to investigate whether the novel PIGT variant resulted in a functional defect, the abundance of GPI-anchored proteins and GPI-anchors were studied in patient cells by flow cytometry. Fluorochrome conjugated antibodies were used to measure the levels of the GPI-anchored proteins CD14, CD16, CD24, CD48, CD49, and CD90 in subsets of ...
Role of CD14 in host protection against infections and in
WebNov 15, 1991 · The GPI-linked human molecules CD59, CD55, CD48, CD24, and CD14 as well as the mouse molecules Thy-1 and Ly-6 were found to associate with protein tyrosine kinases, key regulators of cell activation and signal transduction. Binding of ligand or antibody to certain cell-surface proteins that are anchored to the membrane by … WebOct 22, 2014 · LBP facilitates extraction of LPS monomers by CD14 protein most likely by changing the arrangement of LPS aggregates [10, 11]. CD14 is a GPI-anchored glycoprotein found on the surface of the plasma membrane of monocytes, macrophages, dendritic cells, and at a lower level, neutrophils [12, 13]. It is a horseshoe-shaped dimer … it is as it should be
Chicken CD14, unlike mammalian CD14, is trans …
WebPositioned at the C-terminus of many eukaryotic proteins, the glycosylphosphatidylinositol (GPI) anchor is a posttranslational modification that anchors the modified protein in the outer leaflet of the cell membrane. The GPI anchor is a complex structure comprising a phosphoethanolamine linker, glycan core, and phospholipid tail. GPI-anchored proteins … CD14 (cluster of differentiation 14) is a human protein made mostly by macrophages as part of the innate immune system. It helps to detect bacteria in the body by binding lipopolysaccharide (LPS), a pathogen-associated molecular pattern (PAMP). CD14 exists in two forms, one anchored to the membrane by a … See more CD14 acts as a co-receptor (along with the Toll-like receptor TLR 4 and MD-2) for the detection of bacterial lipopolysaccharide (LPS). CD14 can bind LPS only in the presence of lipopolysaccharide-binding protein (LBP). … See more CD14 is expressed mainly by macrophages and (at 10-times lesser extent) by neutrophils. It is also expressed by dendritic cells. The soluble form of the receptor (sCD14) is … See more • Human CD14 genome location and CD14 gene details page in the UCSC Genome Browser. • Overview of all the structural information available in the PDB for UniProt: P08571 (Monocyte … See more CD14+ monocytes can differentiate into a host of different cells, including dendritic cells, a differentiation pathway encouraged by See more CD14 has been shown to interact with lipopolysaccharide-binding protein. See more WebFaramarz Naeim MD, ... Ryan T. Phan PhD, in Atlas of Hematopathology (Second Edition), 2024 2.1.5.2 CD14. CD14 is a lipopolysaccharide-binding protein, which functions as an … it is a sin not to pray