WebThe Zyto Light SPEC ERBB2/CEN 17 Dual Color Probe (PL8) is intended to be used for the qualitative detection of amplifications involving the human ERBB2 gene as well as the … WebHER2 is a protein that helps breast cancer cells grow quickly. Breast cancer cells with higher than normal levels of HER2 are called HER2-positive. These cancers tend to grow and spread faster than breast cancers that are HER2-negative, but are much more likely to respond to treatment with drugs that target the HER2 protein.
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WebSpringer WebOct 4, 2012 · Background One-third of breast cancers display amplifications of the ERBB2 gene encoding the HER2 kinase receptor. Trastuzumab, a humanized antibody directed against an epitope on subdomain IV of the extracellular domain of HER2 is used for therapy of HER2-overexpressing mammary tumors. However, many tumors are either natively … granite countertop layout
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WebJun 17, 2024 · Our optimized method achieved 100% concordance for the HER2 FISH NordiQC - Quality Control 2015 evaluation, 100% concordance for genotyping and clerical accuracy for the sarcoma panel containing … WebHER2 (ERBB2) Amplification The ERBB2 (erb-b2 receptor tyrosine kinase 2) gene, located at 17q12, is a member of the epidermal growth factor (EGF) receptor family1. ERBB2 amplification is seen in approximately 15% of breast cancers2and, in the absence of therapy, is associated with a poor prognosis for the patient3. WebThis process utilises Cytocell’s proprietary BAC clone collection containing >220,000 clones to produce fully quality-assured custom FISH probes for virtually any sequence in the entire human genome. Based on your specific interests and research, custom FISH probes may range from a simple catalog probe modification to a truly unique product. granite countertop kitchen sink