Ctr1 inhibitor
WebDec 12, 2024 · Cisplatin induces apoptosis in LLC-PK1 cells via activation of mitochondrial signaling pathways and inhibition of this specific pathway may provide a strategy to minimize cisplatin-induced nephrotoxicity. 269 PDF View 1 excerpt, references background
Ctr1 inhibitor
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WebJul 14, 2010 · The studies described in this report suggest that cisplatin-induced ototoxicity and cochlear uptake can be modulated by administration of a CTR1 inhibitor, copper … WebOct 15, 2010 · The Ctr1 protein is a high-affinity Cu+ importer that is structurally and functionally conserved in yeast, plants, fruit flies, and humans and that, in all of these …
WebNov 22, 2011 · The robust inhibition of ethylene responses in eto1, ctr1, and ACC-supplied wild-type seedlings suggested that Kyn modulates the activity of the ethylene signaling … WebJul 12, 2024 · PDF Hearing loss is often caused by death of sensory hair cells (HCs) in the inner ear. HCs are vulnerable to some ototoxic drugs, such as... Find, read and cite all the research you need on ...
WebSep 9, 2013 · CTR1, a high affinity Cu transporter, and CTR2, a low affinity Cu transporter belong to the family of copper transporters found in humans. CTR1 is a 32 kDa, membrane protein consisting of … WebJul 14, 2010 · Other studies showed that using a CTR1 inhibitor copper sulfate to pretreat HEI-OC1 cells also effectively reduced the apoptosis caused by cisplatin, providing another hope for treating CIO [70 ...
WebMar 27, 2024 · Loop diuretics act in the thick ascending limb of Henle and inhibit sodium and chloride ion reabsorption in the kidney. These drugs also inhibit a sodium–potassium–chloride transporter found in the inner ear, …
WebA CTR1 substrate, copper sulfate, decreased the uptake and cytotoxicity of cisplatin in HEI-OC1, a cell line that expresses many molecular markers reminiscent of OHCs. Small … chrome password インポートWebFeb 17, 2024 · We identify that CTR1 undergoes AMPK-mediated phosphorylation, which enhances CTR1 stabilisation and membrane translocation by affecting Nedd4l interaction, resulting in increased oncogenic roles ... chrome para windows 8.1 64 bitsWebCopper transporter 1 (CTR1) represents an important determinant of cisplatin resistance. A series of 35 semi-substituted steroids were recently investigated on cisplatin-resistant … chrome password vulnerabilityWebC1 inhibitor (C1INH) is a 105 kDa plasma protein, which is the only serine protease inhibitor known to dissociate the activated C1r and C1s from C1q, thus limiting the time … chrome pdf reader downloadWebJan 23, 2024 · Unexpectedly, the nuclear-localized CTR1 enhances ethylene responses through a mechanism that does not require its kinase activity. This inhibits the fast recovery of seedling growth back to... chrome pdf dark modeWebDec 12, 2024 · Studies of cisplatin-induced ototoxicity and cochlear uptake show that it can be modulated by administration of a CTR1 inhibitor, copper sulfate. In mice, intratympanic administration of copper sulfate given before intraperitoneal cisplatin dosing prevented subsequent hearing loss. chrome park apartmentsWebNov 6, 2012 · CTR1 consists of a unique N-terminal regulatory domain and a C-terminal serine/threonine kinase domain ( Fig. 1 A ). Because CTR1 is most similar in sequence … chrome payment settings