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Cisplatin atherosclerosis

WebOct 31, 2024 · It has been found that cisplatin may induce DNA damage and cancer cell death also by induction of oxidative stress, particularly the overproduction of mitochondrial reactive oxygen species (ROS) and by decreasing the pool of intracellular antioxidants, e.g. reduced glutathione (GSH). WebMar 24, 2024 · Having an atherosclerosis-related disease may cause fear, anxiety, depression, and stress. You may worry about having heart problems or making lifestyle changes that are necessary for your health. Talk with your healthcare team about how you feel and actions you can take. Talk to a counselor.

Impact of platinum-based chemotherapy on the progression of atherosclerosis

WebMar 27, 2024 · Cisplatin (CisPt) is an alkylating drug that has been successfully used for decades to treat solid organ tumours such as lung, testis or ovarian cancers, resulting in an increased life expectancy for patients. WebAug 13, 2024 · Cisplatin was dissolved in dimethylformamide, and other chemicals were dissolved in dimethyl sulfoxide (DMSO) upon receipt. All chemicals were aliquoted and stored at −80 °C. Cell culture The... nottingham nh reenactment https://theresalesolution.com

Chemotherapy side effects: A cause of heart disease?

WebFeb 16, 2024 · severe or ongoing nausea and vomiting; vision problems, pain behind your eyes; hearing problems, ringing in your ears; pain, redness, swelling, or skin changes … WebAug 14, 2024 · Lipopolysaccharide (LPS) is an endotoxin that induces systemic inflammatory responses. Melittin, a main constituent of bee venom, exerts several biological activities such as antioxidant, anti-inflammatory, and antiapoptotic actions. However, whether melittin protects against endotoxin-induced AKI remains undetermined. WebJul 1, 2016 · Nephrotoxicity is a well documented adverse effect of cisplatin use, with a dose-dependent and irreversible reduction in renal function. 75, 76, 77 Possible mechanisms include endothelial and epithelial cell damage and dysfunction. 78 Patients treated with cisplatin-based chemotherapy have a high prevalence of microalbuminuria … nottingham nh property record cards

Coronary Atherosclerotic Plaque Regression - American …

Category:National Center for Biotechnology Information

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Cisplatin atherosclerosis

Synthesis of siRNA nanoparticles to silence plaque-destabilizing …

WebRecently, a genome-wide analysis of cisplatin-induced peripheral neuropathy in survivors of adult-onset cancer reported that genetically determined expression level of RPRD1B …

Cisplatin atherosclerosis

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WebFeb 1, 2024 · Cis-diamminedichloroplatinum (cisplatin) is an effective agent for treating solid tumors. However, its clinical use is limited by its serious toxic side effects; … WebAcute clinical syndromes associated with cisplatin infusion include chest pain, palpitations, and, occasionally, elevated cardiac enzymes indicative of myocardial …

WebNational Center for Biotechnology Information WebCisplatin causes direct and acute endothelial toxicity with a propensity to arterial thrombosis, irrespective of the presence of underlying atherosclerosis.7 Any longer …

WebNov 5, 2024 · Since its introduction in the late 1970s, cisplatin-based chemotherapy (CBCT) has revolutionized the treatment of metastatic testicular cancer (TC) and … WebJul 1, 2024 · Atherosclerosis is a specific type of arteriosclerosis. Atherosclerosis is the buildup of fats, cholesterol and other substances in and on the artery walls. This buildup is called plaque. The plaque can …

WebNational Center for Biotechnology Information

WebOct 11, 2024 · Weakening of the heart muscle (cardiomyopathy) Heart rhythm problems (arrhythmia) Heart attack Stroke High blood pressure Blood clots Whether you're at risk … how to show a line break in a quoteWebDec 30, 2024 · Cisplatin causes direct and acute endothelial toxicity with a propensity to arterial thrombosis, irrespective of the presence of underlying atherosclerosis. … how to show a line is invariantWebDec 30, 2024 · However, cardiovascular toxicity is a major concern. In addition to acute endothelial toxicity and associated risk of arterial thrombosis, accelerated atherosclerosis may be the result of chemotherapy-associated latent cardio-metabolic dysfunction. A 45-year-old man began treatment with cisplatin-based chemotherapy for testicular cancer. how to show a line break in poetryWebDec 1, 2024 · Europe PMC is an archive of life sciences journal literature. nottingham nhs hospital jobsWebAtherosclerosis is characterized by vascular obstruction from the deposits of plaque, resulting in reduced blood flow. Plaque rupture and the consequent thrombosis may lead to sudden blockage of the arteries and cause heart attack. how to show a list in powerpointWebOct 6, 2024 · The potential exists to alter the course of atherosclerosis with anti-inflammatory drugs. With increased understanding of the specific mechanisms that … nottingham nh to portsmouth nhWebSep 1, 2024 · Cohort 1: Early effects of cisplatin-based chemotherapy Vascular function Participant characteristics are presented in Table 1. %FMD decreased 24 h after the first dose of cisplatin in the 10 patients managed with 3 to 4 cycles of BEP (16.7 ± 1.6 at baseline vs. 10.9 ± 0.9 at 24 h after cisplatin; p = 0.003) ( Figure 2 ). how to show a man he is needed